Includes bibliographies and index.
|Statement||edited by Bernardo Rudy, Linda E. Iverson.|
|Series||Methods in enzymology -- vol. 207, Methods in enzymology -- vol. 293, Methods in enzymology -- vol. 294|
|Contributions||Iverson, Linda E., 1953-, Conn, P. Michael., Rudy, Bernardo.|
|The Physical Object|
Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of Cited by: Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion Channel Pharmacology (ICP) is a research and development enterprise involved in studying drugs that bring about their effects by modulating ion channel functions. Most drugs, one way or another, modulate ion channels either by activating or blocking them. In summary, ion channels are the integral membrane proteins which are usually present as assemblies of many subunit proteins [16, 19]. In most voltage-gated ion channels, α subunit is the pore-forming subunit, while β and γ are the auxiliary rajasthan-travel-tour.com: Kaneez Fatima Shad, Saad Salman, Saifullah Afridi, Muniba Tariq, Sajid Asghar.
Ion transport in and out of the cell across the surface membrane, or among different intracellular compartments are mediated by membrane proteins known as “ion channels,” pumps, and transporters. This book focuses on the first group of proteins. Ion channels are considered to be gated pores whose opening and closing may be intrinsic or. Jul 01, · Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation/5. In a set of four interrelated volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signaling phenomena in living cells. The fourth volume is devoted to Voltage-gated Channel Families, including those molecular complexes activated or modulated by calcium, potassium, and. Overview: Ion channels are pore-forming proteins that allow the flow of ions across membranes, either plasma membranes or the membranes of intracellular organelles (Hille, ). Many ion channels (such as most Na, K Ca and some Cl channels) are gated by voltage but others (such as certain K and Cl channels, TRP channels, ryanodine receptors and IP 3 receptors) are relatively voltage.
Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. The amino acid sequences of many different ion channel proteins have been determined, and in a few cases the X-ray crystal structure of the channel is known as well. Based on their structure, the majority of ion channels can be classified into six or seven superfamilies. For potassium-selective channels, which are among the best-characterized ion channels, four homologous transmembrane. Understanding the physical structure of ion channels is obviously the key to sorting out how they actually work. For instance, much insight into the detailed operation of ion channels has come from recent X-ray crystallographic studies of a bacterial K+ channel (Figure ). This particular molecule was chosen for analysis because the large quantity of channel protein needed for Cited by: 2. It is worth noting that bacteria have several voltage-gated ion channels (4,41,42). This is an interesting observation in conjunction with the fact that different neural ion channels have their.